GSK3B induces autophagy by phosphorylating ULK1
نویسندگان
چکیده
منابع مشابه
AMPK activates autophagy by phosphorylating ULK1.
In eukaryotes, macroautophagy (hereafter, autophagy) functions as a highly conserved catabolic mechanism in which cytoplasm, including damaged organelles and protein aggregates, is sequestered into autophagosomes, double-membrane vesicles, for ultimate degradation and recycling in lysosomes. Autophagy has attracted increasing attention in recent years because of its significance in various aspe...
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Autophagy is a cytoprotective process, which occurs following temozolomide (TMZ) treatment, and contributes to glioma chemoresistance and TMZ treatment failure. However, the molecular mechanisms by which TMZ induces autophagy are largely unknown. In the current study, the ataxia‑telangiectasia mutated (ATM) inhibitor KU‑55933, adenosine monophosphate‑activated protein kinase (AMPK) inhibitor co...
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The expression of the core autophagy kinase, Unc51-like kinase 1 (ULK1), is regulated transcriptionally and translationally by starvation-induced autophagy. However, how ULK1 is regulated during hypoxia is not well understood. Previously, we showed that ULK1 expression is induced by hypoxia stress. Here, we report a new ULK1-modulating microRNA, miR-93; its transcription is negatively correlate...
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Autophagy is a vital lysosomal degradation pathway that serves as a quality control mechanism. It rids the cell of damaged, toxic or excess cellular components, which if left to persist could be detrimental to the cell. It also serves as a recycling pathway to maintain protein synthesis under starvation conditions. A key initial event in autophagy is formation of the autophagosome, a unique dou...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2021
ISSN: 1226-3613,2092-6413
DOI: 10.1038/s12276-021-00570-6